Title

Liver tests in dogs receiving anticonvulsant drugs (diphenylhydantoin and primidone).

SelectedWorks Author Profiles:

Norine E. Noonan

Document Type

Article

Publication Date

1981

Date Issued

January 1981

Date Available

June 2013

ISSN

0587-2871

Abstract

Two groups of adult female dogs were given diphenylhydantoin or primidone orally for 82 days. Plasma glutamic-pyruvic transaminase (GPT), alkaline phosphatase (AP) and gamma-glutamyl transferase (GGT) activity, total plasma bilirubin (TBR) concentration, fasting bile acid level and percent sulfobromophthalein (% BSP) retention were determined in the dogs prior to and after treatment. Plasma GPT and AP showed persistent increases in some dogs, while occasional increases occurred in the remaining dogs in both groups. The plasma enzymes returned to normal 5 wk after treatment. Plasma GGT, TBR, fasting bile acids and % BSP retention were normal during the study.

Comments

Abstract only. Full-text article is available only through licensed access provided by the publisher. Published in Journal of the American Animal Hospital Association, 17(2), 261-264.

Language

en_US

Publisher

American Animal Hospital Association

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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