Title

Variations of plasma enzymes in the pony and the dog after carbon-tetrachloride administration.

SelectedWorks Author Profiles:

Norine E. Noonan

Document Type

Article

Publication Date

1981

Date Issued

January 1981

Date Available

June 2013

ISSN

0002-9645

Abstract

Adult female dogs or pony mares were subjected to a nonlethal dose of CCl4 (0.5 ml/kg body wt). Amounts of several plasma enzymes thought to be indicative of hepatic disease were monitored. Plasma enzymes alanine aminotransferase, aspartate aminotransferase (AST), alkaline phosphatase (ALP), arginase, gamma-glutamyltransferase (GGT) and iditol dehydrogenase (ID) and total plasma bilirubin were determined in these animals before and after the administration of CCl4. In the dog, GGT was not significantly increased but ALP values increased during days 1-6. In the pony, GGT was significantly increased during the entire course of the study but ALP exhibited only small, transient (though significant) increases. Responses of ID, AST and ALP were unremarkable when compared between the pony and dog. Total bilirubin significantly (P .ltoreq. 0.05) increased from days 1-4 (pony) or days 5-8 (dog) after CCl4 dose but returned to or decreased below base-line values. Animals did not have evidence of icterus at any time. The dog and pony were distinct clinical entities and only the appropriate laboratory tests for each species should be used to provide information for the clinicopathologic evaluation of hepatic disease.

Comments

Abstract only. Full-text article is available only through licensed access provided by the publisher. Published in American Journal of Veterinary Research, 42(4), 674-678.

Language

en_US

Publisher

American Veterinary Medical Association

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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