Hossam M. Ashour, Ph.D. Associate Professor, College of Arts and Sciences
Suganthi Sridhar, Ph.D. Associate Professor, College of Arts and Sciences
University of South Florida St. Petersburg
This thesis paper will focus on the most prominent applications in recent research of immunotherapy in neurodegenerative diseases (specifically Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease) with a focus on the cellular level on inflammatory pathways (such as, but not limited to: NFkB, JNK and anti-inflammatory pathways such as NRf2) present in the human body.
The literary analysis will begin with a basic overview of some of the major homeostatic pathways present in cellular organelles within the human body (such as the Unfolded Protein Response/UPR, present in the endoplasmic reticulum of eukaryotes) and how they normally act within a healthy human body. The paper will then delve deeper into how these cellular processes are altered, including the root causes of these neurodegenerative diseases commonly researched today, and what mutations in the normal homeostatic processes mean for the phenotypic display of these illnesses (how symptoms appear).
The final parts of this literary analysis thesis paper will delve into current research methodologies being performed in the neurodegenerative disease therapy field and how immunotherapy is quickly becoming a lead topic of interest amongst researchers and universities and the benefits (and negatives, if any discovered yet) of using immunotherapy compared to the alternative (and maybe currently less effective) therapeutic treatments.
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Sprenger, Kimberly, "Major Neurodegenerative Diseases: A Literary Review of Cellular Immunotherapy in Alzheimer’s, Parkinson’s, and Huntington’s Diseases" (2019). USFSP Honors Program Theses (Undergraduate). 245.